Formulation and Evaluation of Floating Matrix Tablet of Atenolol For
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چکیده
The purpose of this research was to develop gastro-retentive delivery system of atenolol which, after oral administration should have the ability to prolong gastric residence time with desired in vitro release profile. Atenolol was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by direct compression technique, using natural gum such as xanthan gum and guar gum, alone or in combination. The tablets were evaluated for physical characteristics viz. hardness, friability, weight variation, content uniformity, and floating capacity. Further, tablets were evaluated for in vitro release characteristics for 8 hr. Among all the formulations, tablets containing combination of xanthan gum and guar gum showed better floating capacity as well as sustained release of atenolol at the end of 8 hr. The mechanism of release of atenolol from the floating tablets was found to be diffusion couple with erosion. It was concluded that the tablets prepared by combination of xanthan gum and guar gum had efficient floating and sustained release capacity as compared to tablets prepared by using natural gum alone.
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